In recent years, nanotechnology has become more and more widely used in biomedicine, attracting the attention of researchers. Nanobiocomposites have been increasingly researched and applied in nanocarriers, nanomedicines, and nanobiological tissue engineering. In response to the strong demands of researchers, XFNANO customized service projects have added the service content of nano-biocomposite materials such as lipid nanoparticle carrier structures, membrane-coated biomimetic nanostructures, and drug-loading systems. Let's learn about it together~

1. Lipid nanoparticle carrier structure

Lipid nanoparticles (LNP) are clinically approved non-viral nucleic acid delivery systems that can effectively carry out nucleic acid encapsulation, cell delivery and endosomal release. They have many advantages, including high nucleic acid encapsulation rate and effective transfection. ; Enhanced tissue penetration, conducive to transporting nucleic acid molecules; low cytotoxicity and immunogenicity.

We can provide efficient, flexible and high-quality LNP intermediate synthesis solutions, using known or new liposomes to encapsulate nucleic acids (such as mRNA, siRNA, miRNA, pDNA, etc.), small drug molecules, and polymerization Things etc.

Service Content

• LNP encapsulated nucleic acids (mRNA, siRNA, miRNA, pDNA, etc.)

• LNP encapsulated small molecule drugs

• LNP wrapped polymer

2. Membrane-coated biomimetic nanostructures

Cell membrane-coated nanoparticles (CMCNs) are an emerging class of nanocarriers that combine the core properties of nanoparticles with the biological interface properties of cell membranes. Nanoparticles serve as a matrix into which anticancer payloads can be incorporated, or can be tailored for immunostimulatory or photostimulatory functions. At the same time, the cell membrane layer enables CMCNs to effectively interact with surrounding proteins, cells and other biological substrates after in vivo administration. CMCNs technology has the potential to be applied in several therapeutic areas in oncology, including drug delivery, phototherapy, and immunotherapy.

XFNANO customized service projects can provide customized service plans for various types of nanomaterials wrapped in bacterial vesicles, platelet membranes, and red blood cell membranes. If you have special needs, you can also communicate with us.

Service Content

• Bacterial vesicles encapsulating nanoparticles (MOF, mesoporous silica, liposomes)

• Platelet membrane wrapped nanoparticles (MOF, mesoporous silica, liposomes)

•Red blood cell membrane wrapped nanoparticles (MOF, mesoporous silicon, liposomes)

3. Drug loading system

Nanoscale Drug Carriers are a submicron drug carrier delivery system that belongs to the nanoscale microscopic category. Encapsulating drugs in submicron particles can adjust the speed of drug release, increase the permeability of biological membranes, change distribution in the body, and improve bioavailability. Nano-drug carriers commonly used in clinical practice mainly include nano-magnetic particles, polymer nano-drug carriers, nano-liposomes, etc. In recent years, researchers have also begun to try new nanomaterials as drug carriers, such as MOF, black phosphorus, etc.

In addition to providing liposome drug loading solutions, XFNANO customized service projects also have successful experience in polymer micelles, (oxidized) graphene, mesoporous silicon, MOF, black phosphorus nanosheets, and hydrogel drug loading, such as If you have any experimental needs, please contact us.

Service Content

• Liposome drug delivery (temperature-sensitive/acid-sensitive/redox-responsive liposomes)

• Polymer micelles drug loading

• (Oxidized) graphene drug loading

• Mesoporous silicon drug loading

• MOF drug-loaded/fluorescent molecules

• Black phosphorus nanosheets drug-loaded

• Hydrogel drug loading

XFNANO customized services were launched in 2016, including "nano material customization" and "biological customization", covering more than 100 types of nanomaterials and biomaterial cross-design in 14 categories. Personalized services can be provided according to requirements, including verification of experimental ideas. , literature duplication and characterization analysis, etc., to speed up researchers’ experimental process and help research results to reach the top journals as soon as possible!